Benzodiazepines
are medications that are frequently prescribed for symptomatic treatment
of anxiety and sleep disorders. They produce their effects via specific
receptors involving a neurochemical called gamma aminobutyric acid
(GABA). Because they are safer and more effective, Benzodiazepines have
replaced barbiturates in the treatment of both anxiety and insomnia.
Benzodiazepines are also used as sedatives before some surgical and
medical procedures, and for the treatment of seizure disorders and
alcohol withdrawal.
Risk of physical dependence increases if Benzodiazepines are taken
regularly (e.g., daily) for more than a few months, especially at higher
than normal doses. Stopping abruptly can bring on such symptoms trouble
sleeping, gastrointestinal upset, feeling unwell, loss of appetite,
sweating and trembling, weakness, anxiety and changes in perception.
Only trace amounts (less than 1%) of most Benzodiazepines are excreted
unaltered in urine; most of the concentration in urine is conjugated
drug. The detection period for the Benzodiazepines in urine is 3 – 7
days. For more information on benzodiazepines, see
Benzodiazepines Drug
Information.
